Amlodipine is a generic drug for hypertension that can be commonly purchased from any hospital or drug store in India. Bulk supply of the chemical is available with wholesale dealers, manufacturers, and third-party dealers. If you are looking for the end-use medicine as prescribed by the doctor then visit your nearest drug store to purchase it, where it is easily available. However, the buyer finds it difficult to purchase the product for bulk supply and land up paying a hefty amount to the middlemen. This scenario is changing slowly as digitization is taking over the chemical process in the industry.
Purchasing chemicals has just got easy with Carbanio.com, India’s largest B2B online chemical platform. You can now purchase amlodipine in bulk from verified suppliers across India. All you have to do it select the supplier who suits your requirement the best and place an order, the product will reach your doorstep within the given timeframe.
What is amlodipine?
Amlodipine, commonly sold under the brand Norvasc, is a medication to treat high blood pressure, angina (chest pain), and other conditions caused by coronary artery disease. This belongs to the class of drugs known as calcium channel blockers, which relaxes the blood vessels allowing the blood to flow easily. This generic drug has antioxidant properties and also has the ability to increase the production of nitric oxide, an important vasodilator that lowers blood pressure. Amlodipine is the most commonly prescribed medication in the United States, which appeared as the fifth most common medication in the year 2017, with more than 72 million prescriptions. You can now buy amlodipine online at best deals; visit Carbanio.com today!
Amlodipine is sometimes colloquially spelt as allodipine, but the correct spelling still remains amlodipine.
|IUPAC Name||3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate|
|Molecular Weight||408.9 g/mol|
|Melting Point||199-201 ºC|
|Boiling Point||527.2 ºC at 760 mmHg|
|Solubility||Sparingly soluble in water|
Discovery of calcium channel blocker
Calcium channel blocker is a group of medications that interrupt the movement of calcium through calcium channels, thereby relaxing the blood vessels and allowing the blood to flow easily. They are mostly used as a medication to treat patients with high blood pressure. Though calcium channel blockers like amlodipine are commonly used in today’s medicinal field, the experimental work on calcium channels blockers as coronary dilators started in the mid-1960s.
Sidney Ringer, a British clinician, discovered and reported the importance of calcium in muscle contraction in the year 1883. After the discovery by Ringer, 60 years later in the 1940s, Kamada a Japnese scientist and Heibrunn an American scientist studied the intracellular role of calcium. These studies initiated further experiments in the 1960s to understand the pharmacology of calcium function.
The clinician application of calcium channel blockers occurred globally in the 1980s. Amlodipine is a common calcium channel blocker that is available as a generic medication and appears in the list of essential medicines by the World Health Organization. Amlodipine was patented in 1982 and was finally approved for medical use in the year 1990.
Precautions to follow before taking amlodipine
- Ensure to tell your doctor if you have congestive heart failure or liver disease
- In case of high blood pressure, ensure to continue the use of amlodipine even when you feel well
- Drinking alcohol can increase side effects of amlodipine as it further lowers the blood pressure
- Including diet, exercise, and weight management along with amlodipine medication will increase its efficiency multiple folds
- Inform your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. In case, you get pregnant while taking amlodipine, tell your doctor immediately
Side effects of amlodipine
The most common side effects of amlodipine include:
- Edema, the swelling of your legs or ankles
- Stomach pain and abnormal muscle movements
- Irregular heart rate
The rare side effects of amlodipine, which occurs in less than 1% of the time, include:
- Blood disorders
- Peripheral neuropathy
- Gingival enlargement
The toxicity of the most common blood pressure drug, amlodipine, is the ingestion of the drug in excess due to potentially lethal prescription drug overdoses. This can lead to an extreme level of hypotension and shock. The overdose of extended-release formulations can result in bowel ischemia, chest pain, and sudden cardiac collapse.
It is always advised to take the medication as prescribed by the doctor. Amlodipine is available as a liquid in some brands (Amlodipine BESYLATE); some brands suggest you shake well before use while the others should not be shaken, strictly follow the information provided by the manufacturer to avoid any kind of poisoning. In case you fail to understand the instructions, ask your pharmacist to assist you with specific direction for use. Always take the correct dose of the medicine, because the specific dosage is based on your medical condition and response to treatment. The doctor may increase the dosage over a period based on your medical condition; follow your doctor’s instructions carefully.
Amlodipine is a generic drug used for hypertension, angina pectoris, and coronary artery disease. It is prescribed for adults and children above 6 years of age.
Initial dose: 5 mg – 10 mg orally once a day (depending on the symptoms)
Maintenance dose: 5 to 10 mg orally once a day (as prescribed by the doctor)
Maximum dose: 10 mg/day
- Patients who are fragile may be prescribed 2.5 mg orally once a day, which may gradually increase.
- Clinical studies suggest that patients with angina or coronary artery disease may require 10 mg orally once a day.
- The dosage is usually adjusted based on the patient’s response.
Geriatric Dose (for the elderly)
Initial dose: may start with 2.5 mg orally once a day depending on the symptoms
Maintenance dose: 2.5 to 10 mg orally once a day as directed by the doctor
Maximum dose: 10 mg/day
- The dosage should be adjusted on the patient’s response to the medication.
- Amlodipine is used to reduce the risk of hospitalization patients who are recently diagnosed with coronary artery disease.
Pediatric Dose (6 to 17 years)
Maintenance dose: 2.5 to 5 mg orally once a day as prescribed by the doctor
Maximum dose: 5 mg/day orally once a day
- Doses higher than 5 mg have not been studied in pediatric patients due to toxicity issues and health concerns.
- The dosage may vary based on the patient’s response.
Amlodipine: Global Market
The growing competition, market dynamics, market growth, industrial chain, and opportunity analysis has predicted that the amlodipine market will see a huge growth potential. The growing demand of amlodipine will further increase and expected to reach a peak during the year 2020-2026. Over the last few years, 2014-2019, the market has seen a high growth potential and has reassured the players that it will not see downfall anytime soon.
Amlodipine is a pharmaceutical chemical used by end-users in hospitals and drug store, and majorly appears in the market segmentation as 5/20 mg tablets, 10/20 mg tablets, 5/40 mg tablets, and 10/40 mg tablets.
Amlodipine regional market is dominated by North America (USA, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, Columbia etc.), and the Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa).
Top global players of amlodipine include:
- Akzo Nobel
- Finetech Industry
- Wuhan Yuancheng Gongchuang Technology
- Shangyu Jiehua Chemical
- Jiangxi Yongtai Chemical
- Hongye Holding Group
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